Meroterpenoids and a Naphthoquinone from Arnebia euchroma and Their Cytotoxic Activity

Lun Wang; Fu Li; Xin Liu; Bin Chen; Kai Yu; Ming-Kui Wang

doi:10.1055/s-0035-1545693

Planta Medica, Table of Contents

Planta Med 2015; 81(04): 320-326
DOI: 10.1055/s-0035-1545693

Natural Product Chemistry

Original Papers

Georg Thieme Verlag KG Stuttgart · New York

Meroterpenoids and a Naphthoquinone from Arnebia euchroma and Their Cytotoxic Activity

Authors

Lun Wang

¹Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization & Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, Peopleʼs Republic of China

²University of Chinese Academy of Sciences, Beijing, Peopleʼs Republic of China
Fu Li

¹Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization & Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, Peopleʼs Republic of China
Xin Liu

³Beijing Entry-Exit Inspection and Quarantine Bureau, Beijing, Peopleʼs Republic of China
Bin Chen

¹Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization & Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, Peopleʼs Republic of China
Kai Yu

⁴School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, Peopleʼs Republic of China
Ming-Kui Wang

¹Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization & Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, Peopleʼs Republic of China

Abstract

Four new meroterpenoids, arnebinols A–D (1–4), and one new prenylated naphthoquinone, 5,8-O-dimethyl-11-deoxyalkannin (5), together with seven known meroterpenoids (6–12) were isolated from the roots of Arnebia euchroma. The structures of the isolated compounds were elucidated unambiguously by spectroscopic data analysis, as well as X-ray-single crystal diffraction analysis. Arnebinol A (1) and B (2) are rare meroterpenoids possessing a 6/10/5 tricyclic ring system. Compounds 1–12 were evaluated for their cytotoxicities against MG-63 and SNU387 human cancer cell lines. Compound 5 exhibited the most potent activity with IC₅₀ values of 2.69 µM and 6.08 µM, respectively.

Key words

Arnebia euchroma - Boraginaceae - meroterpenoids - arnebinol - cytotoxicity

Full Text

References

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